Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene
نویسندگان
چکیده
منابع مشابه
Sinonasal undifferentiated carcinoma.
PURPOSE The purpose of this paper is to discuss the treatment and outcomes for patients with sinonasal undifferentiated carcinoma. METHODS Review of the pertinent literature. RESULTS Most series contain a limited number of patients treated with various combinations of surgery, radiotherapy (RT), and chemotherapy. Follow-up periods for disease-free patients are sometimes relatively short. Th...
متن کاملSinonasal undifferentiated carcinoma: an update.
PURPOSE OF REVIEW Sinonasal undifferentiated carcinoma is a rare and extremely malignant tumor of the paranasal sinuses. Historically, treatment outcomes have been poor. This review presents recent data on the management of sinonasal undifferentiated carcinoma and examines treatment trends that may result in improved locoregional control and survival. RECENT FINDINGS Patients who receive aggr...
متن کاملSinonasal undifferentiated carcinoma of the maxillary sinus.
We describe the case of a 43-year-old man who was referred to our dental school"s acute care clinic with pain and swelling of presumed dental origin in the left maxillary quadrant. Radiographic examination revealed extensive dental decay and periodontal disease. On questioning, the patient admitted to paresthesia of recent onset. Paresthesia associated with pain or swelling of the jaws is an om...
متن کاملCurrent management of sinonasal undifferentiated carcinoma.
BACKGROUND The management of sinonasal undifferentiated carcinoma (SNUC) remains unclear. Low incidence and poor outcomes make treatment standardization difficult. The objective of this study was to review the used treatment and our outcomes. METHODS From 2001 to 2013, 17 cases of SNUC were treated at our department. Charts were reviewed for standard demographic, tumour size and extension, hi...
متن کاملLeptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma.
BACKGROUND Sinonasal undifferentiated carcinoma (SNUC) is an uncommon neoplasm characterized by local extension and an aggressive course. Treatment often includes a combination of chemotherapy, radiation therapy, and surgery, although the optimal strategy remains unclear. Here, we present the first reported case of leptomeningeal carcinomatosis from SNUC. METHODS AND RESULTS A 28-year-old man...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2021
ISSN: 1471-2407
DOI: 10.1186/s12885-021-08370-x